To increase human growth hormone levels, sermorelin stimulates the pituitary gland to produce greater amounts of natural GH. Critically, sermorelin stimulates natural, endogenous production and is not simply synthetic HGH, a fact which offers several important advantages.
First, overdoses are virtually impossible, as its effects are mediated with negative feedback by the body’s own regulatory mechanisms. As a result, HGH production is unable to reach dangerously high levels, and many of the previously known negative side effects of synthetic HGH administration are avoided.
Second, the body’s own production of growth hormone is enhanced rather than shut down (as occurs with administration of exogenous HGH). Therefore, there is no risk of a hormonal crash upon cessation of sermorelin administration.
Third, there is also no likelihood of a diminishing response to administration as there is with HGH. This is due to Sermorelin’s promotion of enhanced yet natural levels of growth hormone in the body. When administered, synthetic HGH causes growth hormone levels to spike and remain unnaturally constant, which can cause its effectiveness to diminish rapidly over time as the body becomes desensitized to its effects. In maintaining blood levels that more closely resemble the body’s natural fluctuations, sermorelin remains consistently effective at a given dose.
